Hydrides: Labelled compounds, LiBH₄, NaBH₄, SYNHYDRID

Katchem  spol. s r.o. can supply also potassium borohydride, KBH₄,  and after negotiation is able to synthesize cesium and rubidium borohydride, CsBH₄ and RbBH₄.

Isotopic labelled compounds

Isotopic  enrichment :  ¹¹B >99,8%, ¹⁰B >99,5 % , ²D >98%, ⁷Li >99%

   The isotopic purity of all labelled borohydrides is 99.5%; chemical purity of  is 98%+

Lithium borohydrides and labelled lithium borohydrides	Borohydrides and labelled borohydrides	Borazine and labelled borazine	Labelled esters of boric acid, borane-Lewis base complexes
LiBH4	NaBH4	NH3.BH3	(CH3O)310B
LiBD4	NaBD4	NH3.10BH3	(CH3O)311B
Li11BH4	Na11BH4	NH3.11BH3	(n-C4H9O)310B
Li11BD4	Na11BD4	B3N3H6	(n-C4H9O)311B
Li10BH4	Na10BH4	10B3N3H6	(C6H5O)310B
Li10BD4	Na10BD4	11B3N3H6	(C6H5O)311B
7LiBH4	KBH4	10B3N3H12	(C2H5)3 N.BD3
7LiBD4	KBD4		(C2H5)3 N. 10BH3
7Li11BH4	K11BH4		(C2H5)3 N. 11BH3
7Li11BD4	K11BD4		(C2H5)3 N. 10BD3
7Li10BH4	RbBH4		(C2H5)3 N. 11BD3
7Li10BD4	CsBH4		(CH3)2 S. 10BH3
			(CH3)2 S. 11BH3
			(CH3)2 S. 10BD3
			(CH3)2 S. 11BD3
			(CH3)2 S.BD3

   After negotiation, we are able to supply also ¹⁰B and ⁶Li enriched borohydrides and other borane derivatives.

   Contact: Otomar Kříž, Ph.D., executive head, Tel: 420 723 485 723,     e-mail: okriz@katchem.cz

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Lithium borohydride  - LiBH₄

Formula weight	21.78
Chemical purity	min. 95%
Melting point	280oC, decomp.
Density	0.666 g/ml
Solubility	ethers, amines

Lithium borohydride is white crystalline powder which must be handled under protected atmosphere of inert gas. It could be stored in a tightly closed container without frequent opening for several years. If kept in a frequently opened vessel the reagent decomposes rapidly owing to the extremely hygroscopic nature. Contact with cellulose material (paper, cloth, etc.) will generally result in spontaneous combustion within several minutes.
 

Application: Lithium borohydride is versatile reducing agent for reduction of acylchlorides, esters, aldehydes, ketones and epoxides to corresponding alcohols. Carboxylic acids, nitriles and nitro compounds are not reduced. N,N-Disubstituted acid amides are slowly reduced to aldehydes.

Contact: Otomar Kříž, Ph.D., executive head, Tel: 420 723 485 723,     e-mail: okriz@katchem.cz

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Sodium borohydride - NaBH₄

Formula weight	37.83
Chemical purity	99 %
Melting point	400 °C, decomp.
Density	1.074 g/ml
Solubility	DME,DG, liq.NH3, amines

Sodium borohydride is white hygroscopic powder, readily soluble in water and other polar solvents. The aqueous solution can be stabilized by the addition of alkali to give pH of 9. It is insoluble in diethyl ether and slightly soluble in THF. Methanol is a good solvent, but reacts with the reagent. The decomposition can be minimized by adding sodium methoxide.

Application: Sodium borohydride is very mild reducing agent. Aldehydes and ketones are reduced readily to the corresponding alcohols. Acylchlorides may be reduced in the form of their S-triazolinium chlorides to the corresponding aldehydes. Acyclic carboxylic anhydrides are reduced to alcohols and cyclic anhydrides to lactones. Most of other functional groups do not react.

From sodium borohydride can be easy prepared a row of modified reduction agents with selective reduction effect

      (NaBH₄ + AlCl₃, NaBH₄ + BF₃)

   Contact: Otomar Kříž, Ph.D., executive head, Tel: 420 723 485 723,     e-mail: okriz@katchem.cz  

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Sodium bis(2-methoxyethoxo)dihydridoaluminate - SYNHYDRID
NaAlH₂(OCH₂CH₂OCH₃)₂

Katchem spol. s r.o. distributes this compound only in the Czech Republic and neighborough states.

Formula weight	202.16
Concentration in toluene solution	70 ± 1,5 %
Temperature of decomposition	>200 °C
Density of the solution	1.03 g/ml (20°C)
Viscosity (mPa.s/20°C)	cca 65
Solubility	ethers, aromatic hydrocarbons

Sodium bis(2-methoxyethoxo)dihydridoaluminate (SYNHYDRID) is supplied as 70% solution in toluene. After evaporation of toluene is there the possibility to dissolve the residue in benzene, xylene, THF, diethyl ether, etc. In most of cases is sufficient to dilute original toluene solution with chosen solvent. By short-term exposition to moist air (e.g. by ad measurement of the needed amount) arise only negligible losses in the active hydrogen content. Even if the reaction solvent would boil, it is not necessary to protect reaction mixture against the influence of air moisture. Only during long-term reaction process (more than 2 hours) is recommended to protect the reaction mixture by standard way (solid sodium hydroxide or silica gel). SYNHYDRID is highly reactive but as against to it, it is very stable to air oxygen oxidation. High thermal resistance enables quite safe reduction course by 170°C.
Contact of SYNHYDRID with cellulose material (paper, cloth, etc.) will generally result in spontaneous combustion within several minutes. For the decontamination dry sand is recommended.

Application: SYNHYDRID is safe and selective reduction agent and as a rule can well substitute in chemical production much more dangerous Lithium aluminium hydride. SYNHYDRID is used for reductions in organic laboratory as well as in industry. Reduced compound is usually dosed in parts to SYNHYDRID solution in reaction vessel. Because of high SYNHYDRID stability, reverse dosage is also possible. SYNHYDRID is able selectively reduce compounds containing in molecule carbonyl and carboxyl groups as aldehydes, ketones, oxims, carboxylic acids, esters, anhydrides, acylhalogenides, lactons, amides, imides, lactams, nitrils, nitrocompounds and halogenated hydrocarbons. SYNHYDRID is especially suitable for continuous isothermic polymerization of 6-caprolactame by temperature up to 170°C.

Contact:
Bohuslav Čásenský, Ph.D., director, executive head, Tel: +420 266 173 148, e-mail: casensky@katchem.cz

Otomar Kříž, Ph.D., executive head, Tel: 420 723 485 723, e-mail: okriz@katchem.cz      BACK